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Test Code TSHC THYROID FUNCTION CASCADE

Important Note

The testing cascade is represented below:

TSH RESULT: <0.100 0.100-0.270 0.270-4.200 >4.200
 

T4F is reflexed*

 

*If T4F >0.9 but <1.7 T3 is reflexed

T4F is reflexed NO REFLEXES

T4F is reflexed &

TPOAB is reflexed

T4F: THYROXINE FREE

T3: TRIIODOTHYRONINE

TPOAB: THYROPEROXIDASE ANTIBODIES

Additional Codes

Software Test Code
Label Text                                TSHC
EPIC LAB20288                                    

Performing Laboratory

NorDx Laboratories

Useful For

Screening of thyroid disease

Method Name

Electrochemiluminescent Immunoassay (ECLIA)

Reference Values

TSH:

Female
0 - < 5 years: 0.84 - 6.22 µIU/L
5 - < 10 years: 0.48 - 4.81 µIU/L
10 - < 15 years: 0.76 - 4.20 µIU/L
15 - < 20 years: 0.45 - 4.50 µIU/L

Male
0 - < 5 years: 0.84 - 6.22 µIU/L
5 - < 10 years: 1.18 - 5.33 µIU/L
10 - < 15 years: 0.76 - 4.20 µIU/L
15 - < 20 years: 0.64 - 5.37 µIU/L

All Patients ≥ 20 years: 0.270 - 4.20 µIU/mL

 

T4, free (if indicated): 0.9 – 1.7 ng/dL

 

Triiodothyronine, Total (if indicated): 80 – 200 ng/dL

 

TPO antibodies (if indicated): Negative (≤100 U)

Days and Times Test Performed

Monday through Sunday

TSH, FREE T4 AND T3

Tuesday through Thursday

TPO ANTIBODIES

Report Available

1 Day

5 days if reflexed to TPO antibodies

Specimen Type

Serum

Preferred Container

Serum Separator Tube (SST)

Preferred Volume

Serum: 2 mL (Serum Separator Tube (SST))

Minimum Volume

Serum: 1 mL (Serum Separator Tube (SST))

Specimen Collection and Handling

Spin specimen, separate from clot and send refrigerated. If testing will be delayed >48 hours, separate and freeze serum.

Specimen Stability Information

Specimen Type: Serum

Frozen: 30 Days

Refrigerated: 48 Hours

Room Temp: 8 Hours

Note: If testing will be delayed >48 hours, separate and freeze serum.

Add On Capable

Yes

Advance Beneficiary Notice Requirements

This test, when ordered on Medicare patients, is subject to the National Coverage Determination (NCD) policies. Please verify that the diagnosis code (ICD code) you have chosen demonstrates medical necessity for the test as documented in the physician’s patient record. The CMS web site is available to assist you with this verification. A properly executed Advance Beneficiary Notice (ABN) must be submitted with the specimen if medical necessity is not demonstrated by the ICD code chosen.

CPT Code Information

CPT Code

CPT Description

CPT Disclaimer

84439 Thyroxine, Free, Quantitative if Indicated
84443 Thyroid Stimulating Hormone (TSH), Quantitative  
84480 Triidothyronine T3, Total (TT-3), Quantitative if Indicated
86376 Microsomal Antibodies (eg: Thyroid or Liver-Kidney), Each if Indicated

Performing Laboratory Location

NorDx Laboratories

Clinical Significance

If thyroid stimulating hormone (TSH) is <0.270 µIU/mL, then free Thyroxine (FT4) is performed at additional charge.

If TSH is <0.100 µIU/mL and FT4 is within normal range, then total triiodothyronine (T3) is performed at an additional charge. If TSH is >4.200 µIU/mL, then FT4 and thyroperoxidase (TPO) antibodies is performed at additional charge.

Maximum Laboratory Time

5 Days

Acceptable Alternative Container(s)

Red Top Tube