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Test Code PSAFT PROSTATE-SPECIFIC ANTIGEN (PSA), TOTAL AND FREE

Additional Codes

Software Test Code
Label Text                                   PSAFT
EPIC LAB10314                                   

Performing Laboratory

NorDx Laboratories

Useful For

Measuring levels of prostate specific antigen (PSA)

 

The measured PSAFT values of a patient’s sample can vary depending on the testing procedure used. PSAFT values determined on patient samples from different manufacturers cannot be directly compared with one another and could be the cause of erroneous medical interpretations.  

Method Name

Electrochemiluminescent Immunoassay (ECLIA) via Roche Diagnostics Instrumentation

Reference Values

PSA: 4.0-10.0 ng/mL

% Free PSA: >25

Days and Times Test Performed

Monday through Sunday

Report Available

1 Day

Profile Information

Individual Test Description
PROSTATE-SPECIFIC ANTIGEN, FREE
PROSTATE-SPECIFIC ANTIGEN, FREE, PERCENT
PROSTATE-SPECIFIC ANTIGEN, TOTAL

Specimen Type

Serum

Preferred Container

Serum Separator Tube (SST)

Preferred Volume

Serum: 1 mL (Serum Separator Tube (SST))

Minimum Volume

Serum: 0.5 mL (Serum Separator Tube (SST))

Specimen Collection and Handling

1. Spin specimen, separate from clot and send refrigerated.

2. PSA specimens should be drawn prior to prostatic manipulations such as DRE, prostatic massage, transrectal ultrasound (TRUS), and prostatic biopsy.
These procedures may falsely elevate PSA values.

Specimen Stability Information

Specimen Type: Serum

Frozen: 3 Months

Refrigerated: 3 Days

Must be spun/separated within: 2 Hours

Add On Capable

Yes

Advance Beneficiary Notice Requirements

This test, when ordered on Medicare patients, is subject to the National Coverage Determination (NCD) policies. Please verify that the diagnosis code (ICD code) you have chosen demonstrates medical necessity for the test as documented in the physician’s patient record. The CMS web site is available to assist you with this verification. A properly executed Advance Beneficiary Notice (ABN) must be submitted with the specimen if medical necessity is not demonstrated by the ICD code chosen.

CPT Code Information

CPT Code

CPT Description

CPT Disclaimer
84153 Prostate Specific Antigen (PSA), Total  
84154 Prostate Specific Antigen (PSA), Free  

Keywords

PSA (PROSTATE-SPECIFIC ANTIGEN)

PSA FREE

PSA TOTAL

Performing Laboratory Location

NorDx Laboratories

Clinical Significance

In people over 50 with total PSA between 4.0 ng/mL and 10.0 ng/mL, the measurement of the % free PSA may aid in avoiding unnecessary biopsies. A number of studies have found that the % free PSA was significantly lower in patients having prostate cancer than those with benign disease. Elevated levels of prostate specific antigen (PSA) have been associated with benign and malignant prostate disorders. Studies show that in men 50 years or older, measurement of PSA is a useful addition to the digital rectal exam in the early detection of prostate cancer. In addition, PSA decreases to undetectable levels following complete resection of the tumor and may rise again with recurrent disease or persist with residual disease. Thus, % free PSA has been demonstrated to improve the sensitivity and specificity in patients with total PSA values in the “gray zone” of 4.0-10.0 ng/mL.

Acceptable Alternative Container(s)

Plasma Separator Tube (PST)

Red Top Tube