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Test Code PHENO PHENOBARBITAL

Additional Codes

Software Test Code
Label Text                                         PHENO
EPIC LAB30                           

Performing Laboratory

NorDx Laboratories

Clinical Significance

Phenobarbital is a general central nervous system suppressant that has proven effectiveness in the control of generalized and partial seizures. It is frequently co-administered with phenytoin for control of complex seizure disorders and with valproic acid for complex parietal seizures.

Useful For

Monitoring appropriate therapeutic levels of phenobarbital

Method Name

Immunoassay (IA)

Reference Values

Therapeutic concentration: 15.0-40.0 ug/mL

Toxic concentration: >60.0 ug/mL

 

A correlation between serum phenobarbital concentrations and therapeutic response has not been clearly demonstrated. To treat or prevent seizures in epilepsy, a trough serum concentration between 15-40 ug/mL is recommended. For other indications, including alcohol withdrawal or status epilepticus, higher trough serum concentrations may be necessary. Phenobarbital as a half-life of 80 hours so steady-state is achieved after at least two weeks of therapy. 

Days and Times Test Performed

Monday through Sunday

Report Available

1 Day

Available Stat

Specimen Type

Submit one of the following:

~ Plasma

~ Serum

Preferred Container

Plasma Separator Tube (PST)

Serum Separator Tube (SST)

Preferred Volume

Plasma: 0.5 mL (Plasma Separator Tube (PST))

Serum: 0.5 mL (Serum Separator Tube (SST))

Minimum Volume

Plasma: 0.3 mL (Plasma Separator Tube (PST))

Serum: 0.3 mL (Serum Separator Tube (SST))

Specimen Collection and Handling

Spin specimen, separate from clot and send refrigerated.

Specimen Stability Information

Specimen Type: Plasma

Frozen: 3 Months

Refrigerated: 6 Days

Must be spun/separated within: 2 Hours

Note: Freeze at -20 C for long term storage

 

Specimen Type: Serum

Frozen: 3 Months

Refrigerated: 6 Days

Must be spun/separated within: 2 Hours

Note: Freeze at -20 C for long term storage

Acceptable Alternative Container(s)

Red Top Tube

Add On Capable

Yes

CPT Code Information

CPT Code

CPT Description

CPT Disclaimer
80184 Drug Screen Quantitative Phenobarbital  

Performing Laboratory Location

NorDx Laboratories

LOINC Code Information

3948-7

Keywords

LUMINAL® (PHENOBARBITAL)

TDM

THERAPEUTIC DRUG MONITORING

Advance Beneficiary Notice Requirements

No ABN Required