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Test Code MAFP / 010801-LC AFP Open Spina Bifida

Additional Codes

Software Test Code
SoftID                                                  MAFP                                                                   
Integrated Genetics 010801

Performing Laboratory

Integrated Genetics (LabCorp Specialty Testing Group)

Useful For

Screening test for open neural tube defects. Detects 80% of open spina bifida and 90% of anencephaly. Please note that this test does not provide screening for Down syndrome or trisomy 18.

Method Name

Chemiluminescent Immunoassay (CIA)

Specimen Type


Preferred Container

Serum Separator Tube (SST)

Preferred Volume

Serum: 3 mL (Serum Separator Tube (SST)) – Volume requirements are for serum, not whole blood

Minimum Volume

Serum: 0.5 mL (Serum Separator Tube (SST))

Specimen Collection and Handling

Open spina bifida screening is offered for gestational ages 15.0 to 23.9 weeks. The optimal gestational age for open spina bifida screening is 16.0 to 18.9 weeks.

Collect in serum separator tube with gel barrier. Allow blood to clot, avoiding hemolysis. Centrifuge SST tube, separating serum from cells. Transport spun SST tube to testing laboratory. Pouring off serum is not preferred. Maternal serum specimens must be drawn prior to amniocentesis to avoid contamination with fetal blood.

Rejection Information

Gross hemolysis, gross lipemia, quantity not sufficient for analysis, improper specimen type.

Specimen Stability Information

Specimen Type: Serum

Frozen: 14 Days

Refrigerated: 14 Days

Room Temp: 7 Days

Add On Capable

Not Permitted

CPT Code Information

CPT Code

CPT Description

CPT Disclaimer

82105 Alpha-Fetoprotein (AFP), Serum  


Maternal Alpha-Fetoprotein Screening

Maternal AFP

AFP Single Marker