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Test Code HOMCY HOMOCYSTEINE, PLASMA

Additional Codes

Software Test Code
Label Text                                             HOMCY                                                                   
EPIC LAB93

Performing Laboratory

NorDx Laboratories

Useful For

Aiding in the biochemical diagnosis of inborn errors of methionine and related cofactors (folate, vitamin B6, and vitamin B12) metabolism

This test is also useful as an independent risk factor of cardiovascular disease, an indicator of acquired folate or cobalamin deficiency, and as a contributing factor in the pathogenesis of neural tube defects.

Method Name

Chemiluminescent Microparticle Immunoassay (CMIA)

Reference Values

Adults: 0 -13.9 µmol/L

 

Reference values and interpretation apply to fasting specimens only; non-fasting specimens will be rejected.

Days and Times Test Performed

Monday through Friday

Report Available

1 Day

Specimen Type

Plasma

Preferred Container

Lavender Top Tube (EDTA)

Preferred Volume

Plasma: 1 mL (Lavender Top Tube (EDTA))

Minimum Volume

Plasma: 0.5 mL (Lavender Top Tube (EDTA))

Specimen Collection and Handling

1. Draw blood in a lavender-top (EDTA) tube from a fasting patient.

2. IMMEDIATELY spin down and IMMEDIATELY separate plasma from cells.

3. Send 1.0 mL of plasma refrigerated in a plastic screw-capped vial.

 

If unable to immediately separate plasma from cells, place sample on wet ice upon collection.

Sample may be maintained on wet ice for up to 6 hours prior to separation of plasma from cells. Upon separation, sample must be refrigerated.

Specimen Stability Information

Specimen Type: Plasma

Frozen: 3 Months

Refrigerated: 7 Days

Note: Immediately spin specimen or place on wet ice until spun.

Add On Capable

Not Permitted

Advance Beneficiary Notice Requirements

This test, when ordered on Medicare patients, is subject to the National Coverage Determination (NCD) policies. Please verify that the diagnosis code (ICD code) you have chosen demonstrates medical necessity for the test as documented in the physician’s patient record. The CMS web site is available to assist you with this verification. A properly executed Advance Beneficiary Notice (ABN) must be submitted with the specimen if medical necessity is not demonstrated by the ICD code chosen.

CPT Code Information

CPT Code

CPT Description

CPT Disclaimer
83090 Homocysteine, Quantitative  

Performing Laboratory Location

NorDx Laboratories

LOINC Code Information

13965-9

Clinical Significance

The following drugs may elevate levels of homocysteine: methotrexate, carbamazepine, phenytoin, nitrous oxide, anticonvulsants, and 6-azauridine triacetate, The mechanism of action of these drugs affects different parts of the metabolic pathway of homocysteine.

S-adenosyl-methionine is an antidepressant whose molecular form is similar to S-adenosyl-homocysteine.

Rejection Information

Non-fasting specimen