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Test Code ETYGQ / UCETG-MC ETHYL GLUCURONIDE QUANTITATIVE, URINE

Performing Laboratory

Michigan Co-Tenancy Laboratory at Warde Medical Laboratory (MCL)

Useful For

LC/MS/MS confirmation for identification of Ethyl Glucuronide and Ethyl Sulfate in urine.

Method Name

Liquid Chromatography-Tandem Mass Spectrometry (LC-MC/MS)

Reference Values

An interpretive report will be issued

Days and Times Test Performed

Tuesday and Thursday

Report Available

5 Days

Specimen Type

Urine

Preferred Container

Urine Cup

Preferred Volume

Urine: 10 mL (Urine Cup)

Minimum Volume

Urine: 2 mL (Urine Cup)

Specimen Collection and Handling

Collect random urine. Mix well and send 10.0 mL urine (2.0 mL minimum) refrigerated in a screw-capped plastic urine cup.

Specimen Stability Information

Specimen Type: Urine

Frozen: 14 Days

Refrigerated: 14 Days

Room Temp: 2 Days

Add On Capable

Yes

Advance Beneficiary Notice Requirements

This test, when ordered on Medicare patients, is subject to the National Coverage Determination (NCD) policies. Please verify that the diagnosis code (ICD code) you have chosen demonstrates medical necessity for the test as documented in the physician’s patient record. The CMS web site is available to assist you with this verification. A properly executed Advance Beneficiary Notice (ABN) must be submitted with the specimen if medical necessity is not demonstrated by the ICD code chosen.

CPT Code Information

CPT Code

CPT Description

CPT Disclaimer

80321 Alcohol Biomarkers, 1 or 2 (Definitive Drug Testing)
G0480 Drug Test (Definitive), 1-7 Classes Government Payers, if Applicable
G0481 Drug Test (Definitive), 8-14 Classes Government Payers, if Applicable
G0482 Drug Test (Definitive), 15-21 Classes Government Payers, if Applicable
G0483 Drug Test (Definitive), 22+ Classes Government Payers, if Applicable

Clinical Significance

Ethyl glucuronide can be routinely quantified in urine for about 20 hours after a single drink of an ethanol containing beverage (up to 80 hours after heavy ethanol consumption). Both ethyl glucuronide (ETG) and ethyl sulfate (ETS) are metabolites of ethanol. Detection of ETS confirms that the presence of ETG is not a result of in vitro fermentation of sugars. It is known that bacterial fermentation would generate ETG in vitro, but not ETS. Under normal situation, detection of both metabolites concurrently after alcohol consumption is likely. However, due to the genetic polymorphism in the general population, and/or the timing of the specimen collection after drinking, detection of only one metabolite, either ETG or ETS is possible.

Rejection Information

Urine catheter cup (with needle)

LOINC Code Information

2161-8

45324-1

58715-4

60676-4