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Performing Laboratory

NorDx Laboratories

Useful For

Determination of quantitative in vitro estradiol in human serum and plasma

Clinical Significance

Women being treated with fulvestrant will show an increase in estradiol concentrations with this assay. Subsequently, the incorrect level of estradiol may lead to misinterpretations of the hormone status, and the use of fulvestrant may be altered. In addition, the efficiency of anti-estrogen treatment might be underestimated. A medical risk for postmenopausal women under fulvestrant treatment cannot be excluded. Due to the risk of cross-reactivity, this estradiol assay should not be used when monitoring estradiol levels in patients being treated with fulvestrant. Alternative test: Mayo test code, EEST, the methodology by LC-MS/MS. No sample should be collected on patients receiving therapy with high biotin doses (i.e. biotin therapy for Multiple Sclerosis or oncology patients; skin, hair and nail supplements, or multivitamins containing > 5 mg/day) until at least 12 hours after the last biotin administration. If unsure, or if the clinical picture does not fit the results please contact the laboratory. We have methods to check for biotin interference as well as for any other interferences and for the accuracy of the results.

Biotin interference would falsely increase the result of this assay.

Method Name

Electrochemiluminescent Immunoassay (ECLIA)

Reference Values


11.3-43.2 pg/mL


Follicular Phase: 12.4-233 pg/mL

Ovulating: 41.0-398.0 pg/mL

Luteal phase: 22.3-341.0 pg/mL

Postmenopausal: <5.0-138 pg/mL

Days and Times Test Performed

Monday through Sunday

Analytic Time

1 Day

Specimen Type


Preferred Container

Serum Separator Tube (SST)

Preferred Volume

Serum: 1 mL (Serum Separator Tube (SST))

Minimum Volume

Serum: 0.5 mL (Serum Separator Tube (SST))

Specimen Collection and Handling

Spin specimen, separate from clot and send refrigerated.

Patient’s sex is required on request form for processing.

Specimen Stability Information

Specimen Type: Serum

Frozen: 3 Months

Refrigerated: 2 Days

Must be spun/separated within: 2 Hours

Add On Capable


Advance Beneficiary Notice Requirements

No ABN Required

CPT Code Information

CPT Code

CPT Description

CPT Disclaimer

82670 Estradiol, Quantitative

Acceptable Alternative Container(s)

Plasma Separator Tube (PST)

Red Top Tube

LOINC Code Information







Performing Laboratory Location

NorDx Laboratories