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Test Code BENUR / UCBEN-MC BENZODIAZEPINE, QUANTITATIVE, URINE

Important Note

Does not detect Zolpidem (Ambien). Please order Zolpidem (referral miscellaneous test to MCL Warde Lab).

Additional Codes

Software Test Code
SoftID BENUR
EPIC LAB368
Michigan UCBEN

Performing Laboratory

Michigan Co-Tenancy Laboratory at Warde Medical Laboratory (MCL)

Useful For

Confirmation for presence of oxazepam, nordiazepam, temazepam, lorazepam, flurazepam (as 2-hydroxyethylflurazepam), alprazolam (as alpha-hydroxy-alprazolam), clonazepam (as 7-aminoclonazepam)

Method Name

Liquid Chromatography-Tandem Mass Spectrometry (LC-MC/MS)

Reference Values

Negative

LC-MS/MS cutoff concentrations:

Lorazepam: <40 ng/mL

Nordiazepam: <40 ng/mL

Oxazepam: <40 ng/mL

Temazepam: <40 ng/mL

Hydroxyethyl-flurazepam: <40 ng/mL

7-Amino-clonazepam: <40 ng/mL

Alpha-hydroxyalprazolam: <20 ng/mL

Days and Times Test Performed

Monday through Friday

Report Available

2-5 Days

Analytic time for send out tests is the time it will take to perform testing once it has arrived at the performing reference lab. Please add 1 to 2 days from time of collection to allow for receipt at NorDx central lab and shipment of specimen, add another day if specimen is collected on the day before a weekend or holiday. 

Specimen Type

Urine, Random

Preferred Container

Urine Cup

Preferred Volume

Urine, Random: 10 mL (Urine Cup)

Minimum Volume

Urine, Random: 3 mL (Urine Cup)

Specimen Collection and Handling

Collect random urine. Mix well and send urine refrigerated in a screw-capped plastic urine container.

Click here to view the Urine Aliquoting Guide for Processing

Specimen Stability Information

Specimen Type: Urine, Random

Frozen: 14 Days

Refrigerated: 14 Days

Room Temp: 48 Hours

Add On Capable

Contact Reference Lab – If add-on can never be done, report the test to the Administrative Analyst

Advance Beneficiary Notice Requirements

This test, when ordered on Medicare patients, is subject to the National Coverage Determination (NCD) policies. Please verify that the diagnosis code (ICD code) you have chosen demonstrates medical necessity for the test as documented in the physician’s patient record. The CMS web site is available to assist you with this verification. A properly executed Advance Beneficiary Notice (ABN) must be submitted with the specimen if medical necessity is not demonstrated by the ICD code chosen.

CPT Code Information

CPT Code

CPT Description

CPT Disclaimer

80346 Benzodiazepines, 1-12 (Definitive), Quantitative  
G0480 Drug Test (Definitive), 1-7 Classes Government Payers, if Applicable
G0481 Drug Test (Definitive), 8-14 Classes Government Payers, if Applicable
G0482 Drug Test (Definitive), 15-21 Classes Government Payers, if Applicable
G0483 Drug Test (Definitive), 22+ Classes Government Payers, if Applicable

Performing Laboratory Location

Michigan Co-Tenancy Laboratory at Warde Medical Laboratory (MCL)

LOINC Code Information

20412-3

Clinical Significance

INTENDED POSITIVES:

Alprazolam (Xanax)

Chlordiazepoxide (Librium, Librax)

Clonazepam (Klonopin)

Clorazepate (Tranxene)

Diazepam (Diastat, Valium)

Flunitrazepam (Rohypnol, Roofies)

Flurazepam (Dalmane)

Lorazepam (Ativan)

Oxazepam (Serax)

Temazepam (Restoril)

Triazolam (Halcion)