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Test Code BCRQT BCR/ABL, TRANSCRIPT p210, QUANTITATIVE POLYMERASE CHAIN REACTION (PCR)

Important Note

This test may require pre-authorization or have limited coverage.  Please check with your appropriate insurance carrier to determine any specific requirements.

Additional Codes

Software Test Code
SoftID BCRQT
EPIC LAB10822

Performing Laboratory

NorDx Laboratories

Useful For

Detecting only the fusion transcripts that code the p210 protein

This test is usually ordered in conjunction with a pathology consultation. The pathology professional component will be billed separately by the consulting pathologist.

Method Name

Reverse Transcription-Polymerase Chain Reaction (RT-PCR) Quantitative

 

This assay is a lab developed test established by the NorDx Molecular Pathology Laboratory. This laboratory is certified under the Clinical Laboratory Improvement Amendments (CLIA) as qualified to perform high complexity clinical laboratory testing. This test is used for clinical purposes. It should not be regarded as investigational or for research.

Reference Values

BCR/ABL mRNA is detected or not detected.

If detected, the level is reported as a ratio of bcr/abl to abl transcripts. The detection limits of this assay in typical clinical samples ranges from .0001 to .00001 ratio of bcr/abl:abl.

Days and Times Test Performed

Monday through Thursday

Report Available

2 Days

Profile Information

Individual Test Description
INTERPRETATION, BCR-ABL QUANTITATIVE

Specimen Type

Submit one of the following:

~ Bone Marrow

~ Whole Blood

Preferred Container

Lavender Top Tube (EDTA) – Bone Marrow

Lavender Top Tube (EDTA) – Whole Blood

Preferred Volume

Bone Marrow: 4 mL (Lavender Top Tube (EDTA))

Whole Blood: 4 mL (Lavender Top Tube (EDTA))

Minimum Volume

Bone Marrow: 2 mL (Lavender Top Tube (EDTA))

Whole Blood: 2 mL (Lavender Top Tube (EDTA))

Specimen Collection and Handling

Submit only one of the following specimens:

BLOOD OR BONE MARROW:

1. Invert tube several times to mix.

2. Clotted blood is not acceptable.

3. Transport at 2 – 8° C (DO NOT FREEZE).

Specimen Stability Information

Specimen Type: Bone Marrow

Ambient:  24 Hours

Refrigerated: 5 Days

Specimen Type: Whole Blood

Ambient:  24 Hours

Refrigerated:  5 Days

Add On Capable

Not Permitted

Advance Beneficiary Notice Requirements

This test, when ordered on Medicare patients, is subject to the National Coverage Determination (NCD) policies. Please verify that the diagnosis code (ICD code) you have chosen demonstrates medical necessity for the test as documented in the physician’s patient record. The CMS web site is available to assist you with this verification. A properly executed Advance Beneficiary Notice (ABN) must be submitted with the specimen if medical necessity is not demonstrated by the ICD code chosen.

CPT Code Information

CPT Code

CPT Description

CPT Disclaimer
81206 BCR/ABL1 (t(9:22)) Translocation Analysis; Major Breakpoint, Qualitative or Quantitative  

Performing Laboratory Location

NorDx Laboratories

Clinical Significance

Quantitative reverse transcription polymerase chain reaction (qRT-PCR) is the preferred assay for following documented CML patients on tyrosine kinase inhibitors.

Maximum Laboratory Time

10 Days

LOINC Code Information

69380-4

Acceptable Alternative Container(s)

ACD – Bone Marrow

ACD – Whole Blood

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