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Test Code AFPT / 017319-LC α-Fetoprotein (AFP) Tetra Profile

Important Note

This test may require pre-authorization or have limited coverage. Please check with your appropriate

insurance carrier to determine any specific requirements.

Additional Codes

Software Test code
SCC AFPT
EPIC LAB20507
LabCorp 017319

 

Performing Laboratory

Integrated Genetics via LabCorp Laboratories

Useful For

α-Fetoprotein, serum; dimeric inhibin A (DIA); human chorionic gonadotropin (hCG); unconjugated estriol (uE3). Screening test for open neural tube defects (detects 80% open spina bifida, 90% anencephaly), Down syndrome (detects 75% to 80%), and trisomy 18 (detects 73%)

The following information must be provided: gestational age, date on which the patient was the stated gestational age, how gestational age was determined (LMP, EDD, US), patient's weight, patient's date of birth, patient's race (white, black, other), and insulin-dependent diabetic status. Also indicate relevant patient history (eg, prior neural tube defects, Down syndrome, ultrasound anomalies, or previous maternal serum screening specimen during this pregnancy). Complete information is necessary to interpret the test. Patient information may be provided to the laboratory using The Maternal Prenatal Screening requisition form 0900. Specimens must be collected before amniocentesis.

Down syndrome screening is offered for gestational ages 15.0 to 21.9 weeks. Open spina bifida screening is offered for gestational ages 15.0 to 23.9 weeks. The optimal gestational age for open spina bifida screening is 16.0 to 18.9 weeks.

 

Specimen Type

5 mL gold top Serum

minimum volume 3mL

Specimen Collection and Handling

Collect in serum separator tube with gel barrier. Allow blood to clot, avoiding hemolysis. Separate serum from cells by centrifugation. Transport spun tube to testing laboratory.

Pour-off is not advised. Maternal serum specimens must be drawn prior to amniocentesis to avoid contamination with fetal blood.

Additional Notes and Limitations

AFP tetra is a screening test. A positive AFP tetra result means that more diagnostic testing may be offered to the pregnant woman to determine if a neural tube defect or chromosome abnormality is present.

 

Causes for Rejection: Gross hemolysis; gross lipemia; quantity not sufficient for analysis; improper specimen type

 

CPT Code Information

CPT Code CPT Description CPT Disclaimer
81511  Fetal Congenital Abnormalities, Biochemical Assays