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Performing Laboratory

Esoterix Laboratory Services (LabCorp Specialty Testing Group)

Useful For

Screening for congenital adrenal hyperplasia (CAH) caused by either 11-hydroxylase of 21-hydroxylase deficiency; also useful as part of a battery of tests to evaluate females with hirsutism or infertility.

Clinical Significance

NOTE: This test is intended for adult patients only. For pediatric patients, please order 17-HYDROXYPROGESTERONE, PEDIATRIC, SERUM (17HPE).

Method Name

High-Performance Liquid Chromatography-Tandem Mass Spectrometry (HPLC-MS/MS)

Reference Values

Premature (26 to 28 weeks): day 4: 375-3559 ng/dL

Premature (31 to 35 weeks): day 4: 64-2380 ng/dL

3 days: 10-829 ng/dL

1 to 5 months: 36-763 ng/dL

6 to 11 months: 42-540 ng/dL

12 to 23 months: 14-207 ng/dL

24 months to 5 years: 10-103 ng/dL

6 to 9 years: 10-186 ng/dL

Pubertal: 44-235 ng/dL

Adults: 53-357 ng/dL

Specimen Type

Submit one of the following:


Preferred Container

Serum Separator Tube (SST) – serum

Preferred Volume

Serum: 1 mL (Serum Separator Tube (SST)) – 0.1 mL minimum (does not allow for repeat testing)

Minimum Volume

Serum: 0.1 mL (Serum Separator Tube (SST))

Specimen Collection and Handling

Transfer the serum or plasma into an aliquot tube with screw cap and send FROZEN.

To avoid delays in turnaround time when requesting multiple tests on frozen samples, please submit separate frozen specimens for each test requested.

Rejection Information

Nonserum or non-EDTA plasma specimen received

Specimen Stability Information

Specimen Type: Serum

Frozen: 2 Years

Refrigerated: 1 Day

Room Temp: 6 Hours

Note: Stability information also applies to plasma specimens that have been separated from cells.

Add On Capable

Contact Reference Lab – If add-on can never be done, report the test to the Administrative Analyst

CPT Code Information

CPT Code

CPT Description

CPT Disclaimer

84143 17-Hydroxypregnenolone, Quantitative

Acceptable Alternative Container(s)

Lavender Top Tube (EDTA) – plasma

Red Top Tube – serum

Performing Laboratory Location

Esoterix Laboratory Services (LabCorp Specialty Testing Group)