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Important Note

This is only to be used for patients on hormone replacement therapy and patients needing pediatric reference ranges

Performing Laboratory

Esoterix Laboratory Services (LabCorp Specialty Testing Group)

Clinical Significance

This test should be ordered ONLY by a pediatric endocrinology specialist or as a result of consultation with a pediatric endocrinology specialist. For all other patients, please order “ESTRADIOL, SERUM” test code “ESTR2”.

Method Name

High-Performance Liquid Chromatography-Tandem Mass Spectrometry (HPLC-MS/MS)

Reference Values

An interpretive report will be issued

Days and Times Test Performed

Monday through Friday

Analytic Time

4-7 Days

Specimen Type


Preferred Container

Red Top Tube

Preferred Volume

Serum: 3 mL (Red Top Tube) – Minimum volume does not allow for repeat testing.

Minimum Volume

Serum: 1.2 mL (Red Top Tube)

Specimen Collection and Handling

Spin specimen, separate from clot and send frozen within one hour of collection.

Specimen Stability Information

Specimen Type: Serum

Must be spun/separated within: 1 Hour

Add On Capable

Not Permitted

Advance Beneficiary Notice Requirements

This test, when ordered on Medicare patients, is subject to the National Coverage Determination (NCD) policies. Please verify that the diagnosis code (ICD code) you have chosen demonstrates medical necessity for the test as documented in the physician’s patient record. The CMS web site is available to assist you with this verification. A properly executed Advance Beneficiary Notice (ABN) must be submitted with the specimen if medical necessity is not demonstrated by the ICD code chosen.

CPT Code Information

CPT Code

CPT Description

CPT Disclaimer

82670 Estradiol, Quantitative

Acceptable Alternative Container(s)

Serum Separator Tube (SST)

LOINC Code Information




Performing Laboratory Location

Esoterix Laboratory Services (LabCorp Specialty Testing Group)